Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells
نویسندگان
چکیده
Abstract The current study evaluated the anti-cancer properties of bio-functionalized silver nanoparticles fabricated by Juniperus chinensis leaf extracts. were characterized scanning electron microscopy, transmission UV–visible spectroscopy, Fourier transform infrared X-ray diffraction, dynamic light scattering, Zeta potential and spectroscopy. Further, this elucidated cellular molecular mechanisms for anti-proliferative apoptotic effects on human lung cancer cells (A549) compared them with commercial drug cisplatin. size spherical nanoparticle was 12.96 nm negative zeta potential. Up-regulation caspase 3,9 p53, Annexin V-FITC/PI, DAPI staining, ROS production indicated remarkable effect AgNPs to Moreover, down-regulation MMP2/MMP9 scratch matrigel assays revealed anti-metastatic AgNPs. Cell cycle analysis downregulation cyclin D1 cell cessation in G0/G1 phase. Overall, results that green-synthetized had anti-metastasis anti-proliferation comparison cisplatin lower side normal line.
منابع مشابه
Evaluation of Anti-oxidant and Anti-cancer Properties of Silver Nanoparticles Synthesized by Apigenin toward Breast Cancer MCF-7 Cell Line
Introduction: Cancer is one of the most common diseases in the modern societies, which results from the non-stop growth of cells in the body. Due to the advancement of nanobiotechnology, highly effective herbal metabolites can be used to treat cancer. Apigenin is a natural flavonoid that is found in abundance in fruits, vegetables and herbs. The purpose of this study was to investigate the anti...
متن کاملAnti-carcinogenic and anti-angiogenic properties of the extracts of Acorus calamus on gastric cancer cells
Objective: Acorus calamus (A. calamus) has been used as a medicinal plant in Asia for its effects on digestive system for the last 2000 years. To investigate the anti-cancer activity of rhizome of A. calamus, the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (AGS). Materials and Methods: The via...
متن کاملLaser-fabricated castor oil-capped silver nanoparticles
Silver nanoparticles were fabricated by ablation of a pure silver plate immersed in castor oil. A Nd:YAG-pulsed Q-switch laser with 1064-nm wavelength and 10-Hz frequency was used to ablate the plate for 10 minutes. The sample was characterized by ultraviolet-visible, atomic absorption, Fourier transform-infrared spectroscopies, and transmission electron microscopy. The results of the fabricate...
متن کاملWeak Anti-inflammatory and Anti-cancer Properties of Saffron
Background and objectives: Positive role of saffron in human health promotion has been investigated in widespread researches. Anticancer property, neuroprotection, protection of cardiovascular system and several positive properties are reported for saffron customers. The aim of this study was assessment of saffron weakness against light damage in rat retina. Methods:</s...
متن کاملComparative Study of Anti-Cancer Properties of Hydroalcoholic Extract of Different Cultivars of Apricot Kernels on Breast Cancer Cells (MCF7) and Human Umbilical Vein Endothelial Cells
Background and purpose: Breast cancer mortality is growing around the world due to chemotherapy resistance and chemo-related side effects. Many natural products from plants are recognized to exert anticancer activity. This study aimed at investigating anti-proliferative and apoptotic activity of hydro-alcoholic extract of different varieties of apricot kernels (Jahangiri, Palmia, Jafari, and N5...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: AMB Express
سال: 2021
ISSN: ['2191-0855']
DOI: https://doi.org/10.1186/s13568-021-01216-6